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KMID : 0359319940340040727
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Korean Journal of Veterinary Research
1994 Volume.34 No. 4 p.727 ~ p.734
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Effect of calcitonin gene - related peptide , vasoactive intestinal peptide and substance P on isolated renal artery of rabbit
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Abstract
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To elucidate the effect of calcitonin gene-related peptide(CGRP), vasoactive intestinal peptide(VIP) and substance P was investigated with perivascular nerve stimulation and treatment of peptides from polygraph in the isolated renal artery of rabbit.
1. The neurogenic contraction induced by perivascular nerve stimulation was the frequency-dependent manner(264 ㎐) in the isolated renal artery of rabbit.
2. CGRP and VIP caused the relaxation on the precontraction with noradrenaline(10μM) on the presence and absence of endothelium in the isolated renal artery of rabbit.
3. Substance P caused the endothelium-dependent relaxation on the precontraction with noradrenaline(10μM) in the isolated renal artery of rabbit.
4. CGRP and VIP inhibited the neurogenic contraction by the perivascular nerve stimulation(0.3 ㎳, 30 V, 50 ㎐, 1 sec) on the absence and presence of endothelium in the isolated renal artery of rabbit.
5. Substance P inhibited on the neurogenic contraction by the perivascular nerve stimulation with the endothelium-dependent in the isolated renal artery of rabbit
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